摘要：目的 研究飛行員血液同型半胱氨酸(homocysteine,Hcy)水平變化,預測飛行員心血管事件的發生. 方法 將163例飛行員和60例男性健康地面工作人員(對照組)按年齡分別設21～30歲、31～40歲和41～50歲組;同時按飛行時間將飛行員分別設≤1000 h、1001～2000 h、2001～3000 h和3001～4000 h組;采用全自動生化分析儀測定Hcy濃度. 結果 飛行員組血液Hcy濃度為(9.86±4.45)μmol/L,對照組為(7.10±1.77)μmol/L.兩組比較顯示飛行員組血液Hcy明顯高于對照組(t=4.67,P＜0.01);在不同年齡組血液Hcy測定中,對照組21～30歲組與41～50歲組差異顯著(P＜0.05),飛行員不同年齡組之間差異均顯著(P＜0.05或P＜0.01);在不同飛行時間血液Hcy測定中,1001～2000 h組、2001～3000 h組均與≤1000 h組差異顯著(P＜0.01).同一年齡組中,飛行員血液Hcy濃度均高于對照組(t=3.893、6.221、3.193,P＜0.01). 結論 測定血液Hcy可預測飛行員心血管事件發生的危險性,應針對飛行員血液Hcy升高采取強有力的干預措施,從而有效預防飛行員冠心病的發生. Abstract： Objective To study the change of homocysteine (Hcy) concerntration in pilot's blood and to predict the occurrence of cardiovascular events of pilots. Methods One hundred and sixty-three pilots and 60 male health ground service personnel were selected as pilot and control groups and respectively divided by age as 21-30, 31-40 and 41-50 yrs sub-groups. Pilots were also grouped into ≤ 1000 h, 1001-2000 h, 2001-3000 h and 3001-4000 h sub-groups by flying hours. The concentration of Hcy were detected by using automatic biochemical analyzer. Results The Hcy concentration in pilot group was (9.86±4.45) μmol/L comparing to (7.10±1.77) μmol/L in control group and the difference between groups was significant (t=4.67, P＜0.01). For the Hcy change by age, significant differences were between sub-group 21-30 yrs and 41-50 yrs in control group (P＜0.05), and between each two sub-groups in pilot g