Effects of renal sympathetic denervation on cardiac systolic function after myocardial infarction in rats
摘要：This study investigated the therapeutic effects of renal denervation on cardiac systolic function after myocardial infarction(MI) in rats and the mechanism involved.Fifty male SD rats were randomly assigned to the sham group(n = 15),the MI group(n = 20),and the MI plus renal denervation group(n = 15).MI was established through thoracotomic ligation of the anterior descending artery.Renal denervation was achieved by laparotomic stripping of the renal arterial adventitial sympathetic nerve,approximately 3 mm from the abdominal aorta.Left ventricular function and hemodynamics were measured several weeks following MI.The left ventricular systolic function of the MI group was significantly reduced and the systolic blood pressure(SBP) remarkably declined.In rats with MI treated with renal denervation,the left ventricular ejection fraction(EF),fractional shortening(FS) and SBP markedly improved compared with the MI group.However,heart rate and fibrosis decreased significantly.These findings suggest that renal denervation has therapeutic effects on post-MI cardiac dysfunction.These effects are associated with increased left ventricular ejection fraction(LVEF) and SBP,as well as reduced heart rate and fibrosis.This may represent a new approach to the treatment of post-MI remodeling and subsequent heart failure.
注：因版權方要求，不能公開全文，如需全文，請咨詢雜志社。
南京醫科大學學報·自然科學版雜志
南京醫科大學學報·自然科學版雜志， 月刊，本刊重視學術導向，堅持科學性、學術性、先進性、創新性，刊載內容涉及的欄目：基礎研究、基礎醫學、綜述、病例報告、影像醫學、述評、公共衛生與預防醫學研究、影像醫學研究、病毒肺炎研究、公共衛生與預防醫學、預防醫學、口腔醫學研究、技術方法等。于1956年經新聞總署批準的正規刊物。
- 北大期刊
- 統計源期刊
- 1個月內審核
