Autoantibodies in Alzheimer’s disease:potential biomarkers,pathogenic roles,and therapeutic implications
摘要：Alzheimer’s disease(AD) is a prevalent and debilitating neurodegenerative disorder in the elderly.The etiology of AD has not been fully defined and currently there is no cure for this devastating disease.Compelling evidence suggests that the immune system plays a critical role in the pathophysiology of AD.Autoantibodies against a variety of molecules have been associated with AD.The roles of these autoantibodies in AD,however,are not well understood.This review attempts to summarize recent findings on these autoantibodies and explore their potential as diagnostic/prognostic biomarkers for AD,their roles in the pathogenesis of AD,and their implications in the development of effective immunotherapies for AD.
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南京醫(yī)科大學學報·自然科學版雜志
南京醫(yī)科大學學報·自然科學版雜志， 月刊，本刊重視學術(shù)導向，堅持科學性、學術(shù)性、先進性、創(chuàng)新性，刊載內(nèi)容涉及的欄目：基礎(chǔ)研究、基礎(chǔ)醫(yī)學、綜述、病例報告、影像醫(yī)學、述評、公共衛(wèi)生與預防醫(yī)學研究、影像醫(yī)學研究、病毒肺炎研究、公共衛(wèi)生與預防醫(yī)學、預防醫(yī)學、口腔醫(yī)學研究、技術(shù)方法等。于1956年經(jīng)新聞總署批準的正規(guī)刊物。
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