Synthesis, Crystal Structure and Antitumor Activity of N-(5-Aryl-1,3,4-thiadiazol-2-yl)-N'-((E)-styryl)ureas
摘要：N-(5-Aryl-1,3,4-thiadiazol-2-yl)-N?-((E)-styryl)ureas 4 a~4 i were designed and synthesized as antitumor agents, and their structures were characterized by IR, 1 H NMR, 13 C NMR,MS and elemental analysis. The single crystal of compound 4 a, C17 H13 FN4 OS, was also determined by X-ray crystallography. Crystal data: monoclinic, space group P21/n, a = 4.9401(8), b= 8.7100(15), c = 36.604(6) A,β= 93.320(3)°, V = 1572.4(5) A3, Z = 4, F(000)= 704, Dc = 1.438 g/cm3,μ= 0.228 mm-1, R = 0.0600 and wR = 0.1448 for 2743 independent reflections(Rint =0.0418) and 2174 observed ones(I > 2σ(I)). The in vitro antitumor activities of compounds 4 a~4 i were preliminarily evaluated by the standard MTT assay.
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結構化學雜志
結構化學雜志， 月刊，本刊重視學術導向，堅持科學性、學術性、先進性、創新性，刊載內容涉及的欄目：有機化學、無機化學、合成化學、結構化學、材料科學、藥物化學、晶體學、理論化學等。等。于1982年經新聞總署批準的正規刊物。
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